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This is mainly attributed to the high rates of dyslipidemia among diabetic patients which is believed to be one of the major factors accounting for the high percentage of deaths among diabetics due to cardiovascular disease (CVD) .The differences in the lipid profile between diabetics (especially type 2 diabetics) and nondiabetics account for the increased CVD risk .1112, Guangzhou, China E-mail: [email protected]: 86 20 83827812 extn 51157 A rapid, sensitive and selective ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of atorvastatin and all its as-yet-identified metabolites in human plasma.
Essentially, T2DM lipid profiles consist of elevations in triglyceride (TG) levels (2 mmol/L) and reductions in high-density lipoprotein cholesterol (HDL-C).
While low-density lipoproteins cholesterol (LDL-C) concentration levels are normal, the particles are denser and smaller in size, which is believed to enhance their atherogenic potential .
Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes.
The clear evidence of the benefit of statin use coupled with very minimal side effects or long term effects has resulted in this class becoming one of the most widely prescribed medications in North America.