Atorvastatin Thesis

Atorvastatin Thesis-89
This is mainly attributed to the high rates of dyslipidemia among diabetic patients which is believed to be one of the major factors accounting for the high percentage of deaths among diabetics due to cardiovascular disease (CVD) [5].The differences in the lipid profile between diabetics (especially type 2 diabetics) and nondiabetics account for the increased CVD risk [6].1112, Guangzhou, China E-mail: [email protected]: 86 20 83827812 extn 51157 A rapid, sensitive and selective ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of atorvastatin and all its as-yet-identified metabolites in human plasma.

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Essentially, T2DM lipid profiles consist of elevations in triglyceride (TG) levels (2 mmol/L) and reductions in high-density lipoprotein cholesterol (HDL-C).

While low-density lipoproteins cholesterol (LDL-C) concentration levels are normal, the particles are denser and smaller in size, which is believed to enhance their atherogenic potential [7].

Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes.

The clear evidence of the benefit of statin use coupled with very minimal side effects or long term effects has resulted in this class becoming one of the most widely prescribed medications in North America.

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Atorvastatin Thesis

For further information, including about cookie settings, please read our Cookie Policy .By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.Atorvastatin and all five metabolites were eluted within 4 min.Quantification was performed through positive ion electrospray ionization (ESI).The responses of atorvastatin and its metabolites for atorvastatin and its metabolites.The intra- and inter-day precision variations were between 3.3% and 13.9%.Atorvastatin and other drugs from the statin class of medications including lovastatin, pravastatin, rosuvastatin, fluvastatin, and simvastatin are considered first-line options for the treatment of dyslipidemia.Increasing use of the statin class of drugs is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease, and stroke, has become a leading cause of death in high-income countries and a major cause of morbidity around the world.More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-Co A) Reductase, which catalyzes the conversion of HMG-Co A to mevalonic acid.This is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL).

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